But in compound turbocharging, the smaller turbo is sized so there is less spool time and you can have pretty good response, and similar results with sequential. Full twins I think would be less efficient than an RT. About the surge,that's what bov's and wastegates are for anyways.

and you can get turbos with anti-surge housings if you do start surging to help with the problem. This does only really help if you have all your turbo math right from the beginning, if not, you're bound to deal with some difficulties.
Now with RT I think you would have that torque and boost on that engine sooner, say if you just wanted to mash it from the middle of a slow cruise in a gear a bit too high. Also all of the exhaust is going straight to the turbo, and if you have twin-scroll you can utilize those exhaust pulses right instead of through the exhaust housing and wastegate of a smaller charger. There's less exhaust piping and weight, and with a roots style blower there's less intake piping also.
the diplomatic way to say it is it's down to what you're doing with the car and how you want to drive it. But personally I think I'd take RT, two different types of chargers each strong where the other is weak? Besides, you can set it up so you can turn off the supercharger with a switch. That'd really give your car that "super action movie extreme machine" feel to passengers once you show them what it's really made of lol.