The 4th generation Nissan Altima (2008–2013 coupe) is prone to poor CVT operation and failure. Because of these issues, Nissan extended the Altima's powertrain warranty (2007 to 2010 models only) to cover CVT problems for up to 10 years or 120,000 miles. Overheating transmission fluid can cause the CVT to enter a fail-safe mode, which reduces engine power to prevent internal damage. Owners may experience this reduction in performance when driving in hot weather or climbing steep hills. An external transmission cooler is available from Nissan to fix this condition, though prolonged damage may still require CVT repair or replacement.

Owners have also complained about engine starting issues. Nissan identified a fault with the electronic steering column lock (ESCL) of 2009 and 2010 models, which is designed to prevent theft but can inadvertently keep the engine from starting once the vehicle is unlocked. Nissan replaces the component free of charge. Additionally, 2011 and 2012 Altima models may have faulty ignition switch software. Reprogramming the vehicle's body control module (BCM) can fix this issue.