Post by
carbonbridge »
https://forums.nicoclub.com/carbonbridge-u7420.html
Tue May 13, 2003 9:10 pm
YellowPreludeR:
Dear Sir,Please note that Toluene is NOT a water soluble fuel alcohol. Toluene (methylbenzene, toluol, phenylmethane) is an aromatic hydrocarbon (C7H8) commonly used as an industrial solvent for the manufacturing of paints, chemicals, pharmaceuticals, and rubber.
You are dealing with disinformation to think that this product is a fuel alcohol. The toxicity sheet below will give you some highlights. Toluene in gasoline is typically associated with xylene and benzene. The levels of these aromatics in gasoline have been drastically lowered way down by the EPA from the volumes where they used to be just 8 years ago prior to reformulated gasoline's introduction in the USA.
In Israel, the common term for gasoline is "benzene" because their gasoline (and that of many other countries) contains much higher levels of this carcinogenic chemical. I remember 30 years ago that I used to wash car parts in gasoline and put my hands right into it. No more! When I pour a little gasoline into a lawn mower and spill some on my hands, I immediately wash my hands because chemicals like toluene, benzene and xylene can be absorbed right through the skin. Go visit any refinery and look at how they label tanks with these aromatics and/or ask a few employees what they think of this stuff...
You might buy some toluene at the paint store AND your car might run on it, but you are simply polluting the atmosphere even more by doing so. My advice is don't buy this stuff and add more of it to your gasoline. Try some methanol, ethanol or higher mixed alcohols instead.
Nite.
--CarbonBridge
•••••••••••••••••••••••••••••••Toxicity, TolueneLast Updated: November 27, 2001Synonyms and related keywords: methylbenzene, toluol, phenylmethane, huffing, bagging
Introduction Clinical Differentials Workup Treatment Medication Follow-up Miscellaneous Bibliography
Author: Kevin A Martin, MD, Staff Physician, Department of Emergency Medicine, The Toledo Hospital Kevin A Martin, MD, is a member of the following medical societies: American College of Emergency Physicians
Background: Toluene (methylbenzene, toluol, phenylmethane) is an aromatic hydrocarbon (C7H8) commonly used as an industrial solvent for the manufacturing of paints, chemicals, pharmaceuticals, and rubber. It is identified as CAS#108-88-3 and United Nations Department of Transportation's number for toluene is UN#1294.
Toluene is found in gasoline, acrylic paints, varnishes, lacquers, paint thinners, adhesives, glues, rubber cement, airplane glue, and shoe polish. At room temperature, toluene is a colorless, sweet smelling, volatile liquid.
Toxicity can occur from accidental or deliberate inhalation of fumes, ingestion, or absorption through the skin. Toluene abuse or glue sniffing has become widespread, especially among children or adolescents, because it is readily available and inexpensive. Toluene is commonly abused by saturating or soaking a sock or rag with spray paint, placing it over the nose and mouth, and inhaling to get a sensation of euphoria, buzz, or high. Slang names for inhalation include huffing (ie, soaking a sock or rag) and bagging (ie, spraying paint into a plastic bag and inhaling). With bagging, exhaled air is rebreathed and resulting hypoxia and hypercapnia may add to the disorienting effects of the solvent.
The Occupational Safety and Health Administration (OSHA) has determined the acceptable level of occupational exposure to toluene for people in the workplace. Toluene levels of 100 ppm are considered safe for workers. Levels of 150 ppm are acceptable for short periods (<8 h). Toluene levels of 2000 ppm are considered dangerous to life and health. However, some people may be more sensitive to the effects of inhaled solvents than others; occupational asthma has occurred in some workers exposed to toluene levels considered safe in the workplace. For such people, protective equipment should be used and provided by employers, even when toluene levels are in the acceptable range. Workers with a history of asthma induced by solvent exposure should also be warned about and protected from short-term exposure to higher concentrations.
Pathophysiology: Acute intoxication from inhalation primarily affects the CNS, causing euphoria, dizziness, confusion, CNS depression, headache, vertigo, hallucinations, seizures, ataxia, tinnitus, optic neuropathy, peripheral neuropathy, stupor, and coma.
Toluene also may have direct negative effects on cardiac automaticity and conduction and may sensitize the myocardium to circulating catecholamines. Sudden death secondary to cardiac arrhythmias has been reported. Pulmonary effects include bronchospasm, asphyxia, and aspiration pneumonitis.
Long-term toluene exposure or abuse is devastating, affecting the CNS, GI system, liver, kidneys, skeletal muscle, blood, and skin. Chronic CNS sequelae include neuropsychosis, cerebral cortex atrophy, cerebellar degeneration and ataxia, optic and peripheral neuropathies, decreased cognitive ability, blindness, and deafness.
GI symptoms from inhalation and ingestion may result in abdominal pain, nausea, vomiting, and hematemesis. Reported renal toxicity from toluene exposure includes renal tubular acidosis, hypokalemia, hypophosphatemia, hyperchloremia, azotemia, pyuria, hematuria, and proteinuria. Hepatotoxicity manifests with ascites, jaundice, hepatomegaly, and liver failure.
Hematological consequences of exposure may include lymphocytosis, macrocytosis, eosinophilia, hypochromia, and basophilic stippling. Cutaneous contact with skin may range in severity from dermatitis to extensive chemical burns with coagulation necrosis. Toluene affects skeletal muscle; rhabdomyolysis, myoglobinemia, and a severe muscle weakness similar to Guillain-Barré have been reported.
Frequency:
* In the US: Glue is accessible and inexpensive; thus, glue sniffing is becoming widespread. Most frequently, glue sniffing is observed in teenagers and young adults in lower economic groups. An estimated 3-4% of American teenagers engage in sniffing on a regular basis and 7-12% of high school students have tried sniffing at least once. Incidence in young people is rising. Chronic nonintentional exposure also occurs among people in the painting, gasoline, chemical, and rubber industries. The 1998 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System records only 2312 exposures to toluene and xylene combined. Of these, only 15 sustained major adverse outcomes, and no deaths were reported. This report severely underestimates the abuse of this agent.
* Internationally: Solvent abuse is a popular practice around the world. In the United Kingdom, 3.5-10% of children younger than 13 years have abused volatile substances, and 0.5-1% are long-term users. In Singapore, toluene glue sniffing has reached epidemic proportions. In 1980, 24 cases of solvent abuse were reported. By 1984, this number had increased to 763. From 1987-1991, 1781 glue sniffers were identified. In low-income families in Sao Paulo, Brazil, 24% of children had inhaled a volatile substance at some time and 4.9% had inhaled within the last month. Petrol (containing 13% toluene) sniffing has been reported among Native Americans in Canada and Aborigines in Australia.
Mortality/Morbidity: Sudden death is the most serious risk from inhalation of toluene or other volatile substances. Although trauma, aspiration, and asphyxia from plastic bag use are contributing factors to mortality from solvent abuse, 4 direct modes of toxicity leading to death from toluene and other inhaled substances are anoxia, respiratory depression, vagal stimulation, and, most importantly, cardiac arrhythmias.
Volatile substance abuse sensitizes the myocardium to circulating catecholamines. Sudden alarm, exercise, and sexual activity may induce arrhythmias. In many cases of death associated with solvent abuse, fright and running were the immediate antemortem events.
Prolonged exposure to toluene by inhalation is associated with CNS, heart, liver, kidney, and lung damage. Other sequelae include muscle weakness, nasal ulcerations, recurrent epistaxis, chronic rhinitis, neuropsychiatric abnormalities, GI symptoms, and peripheral neuropathies (see Pathophysiology).
Fifty percent of chronic solvent abusers are women in their prime childbearing years. With exposure, toluene crosses the placenta and additional morbidity arises from children born with abnormalities similar to fetal-alcohol syndrome (FAS).
* In the 1960s, a total of 110 cases of sudden death from solvent abuse were reported in the US. In 1988, in the UK, 133 deaths were reported in people aged 11-76 years and from varying social backgrounds; 72% of these deaths occurred in adolescents, and 90% of deaths occurred in males.
* In Singapore, from 1983-1991, 33 people were found to have toluene in their blood postmortem; 22 were known glue sniffers; 11 were suspected of solvent abuse; 6.1% of deaths were from acute toluene poisoning; and 87.9% were associated with falling, drowning, or jumping, which suggests a correlation between the intoxicating effect of toluene and the high incidence of traumatic death of its users.
* From 1983-1991, 4 deaths attributed to occupational exposures were reported in Singapore.
Race: No scientific data indicate that outcomes of toluene exposure are based on race.
Sex: Although typically thought of as an activity of young males (most mortalities occur in young males), more than 50% of chronic solvent abusers are females in their prime childbearing years.
Age: Toluene inhalation is found in people of all ages.
* Most acute cases occur in young males aged 11-19 years who participate in glue sniffing as a group activity.
* Cases have been reported in people aged in their 50s and 60s.