I'll try to give a more objective response than WD. He's quite biased towards alcohol. Not that alcohol is a bad thing. I inject alcohol usually every weekend. Oh wait...we are talking about cars.
Personally, for simplicity, I would try to use larger injectors first on a street car. If you have no desire to run alternative fuels, then you may not need additional injectors. Larger injectors usually suffice. But there are limitations. Injectors work off pulse widths. If you go too big on the injectors the injector driver may not be able to precisley meter fuel at idle and low RPM's because it can not open them and shut them again fast enough. JWT says they can not go beyond 72 lb injectors on a Nissan ECU. In cases like this, you may still need additional injectors. You could go with a simpler set up of one or two or more injectors that spray into the intake pipe before the throttle body to add more fuel. Distribution will be fine as long as you mount it far enough from the throttle body so that it has time to mix evenly. Before throttle injectors have a disadvantage that more of the fuel may get absorbed into the intake piping and manifold walls before it gets to the cylinders. But will still be effective to add more fuel if set-up properly.
Or you can go to a full blown dual stage set-up with an additional injector per cylinder mounted in the intake runners or the like. This is much better for the fuel, but still not as good as direct port injection. Systems like this can be a bit more complicated and are more expensive.
Any kind of supplementary system can be used for alternative fuels, such as alcohol. If alcohol is not easy to access, you can also use race fuel as a supplementary fuel. Personally, I plan to stay away from alternative fuels since gas prices are already high enough as is, and is readily available.
Lastly, there may be some specific properties of a fuel like alcohol. WD can probably hed some light on this. I know Methanol is a form of alcohol, and is very corrosive and also requires more volume of fuel for a given amount of air. But it is very effective in race cars. I believe methanol race cars tend to run primarily on methanol though.