I recently purchased a nice 2000 Nissan Quest for cheap. I also have a line on a supercharger from a Frontier. Will this scharger fit the van?

Unknown. The 2000 Quest has the 3.3L in it but I have not heard of it being done. I know a few Xterra owners have had their non-supercharged vehicles upgraded with the Blower from the 2001 SC models. SO I guess in theory it can be done.

Need to find out if the engine bay has enough room on the accessory side ( belts ) so the snout of the blower can be hooked via a belt in that area. And you need to find out if you have enough hood clearance for the blower.