Pretty much all gasoline [except oxygenated and ethanolized] has the same BTU [+-2%] and it takes the same mount to generate a HP.
The problem with ODB engines is that the system is designed to keep cruise at 14.7 AF [the optimum for cats]..........no matter what you do the system will correct itself.........to provide no excess oxygen in the exhaust prior to the first cat.
Other than designing new O2 sensors, which have a leaner transition point or jeeping the software to accept a leaner cruise, you are stuck with flowing x amount of fuel for y rpm cruise.
The OBD software has a +-20% trim [at cruise] so, if you could fool the ecu you could improve the mileage by 20% if the cats didn't melt or you didn't burn the exhaust valves.
Unfortunately the premium grade motor octane available will knock at much leaner than 6-7% [say 15.7 A/F].
With the CAFE monetary penalties the manufacturers pay, if they could improve mileage by JUST 1 mpg they would gladly spend $250 on changes to each V8 car.
Oxygenated fuels make matters worse as they fool the O2 sensors into to enriching the mixture....that coupled with lower BTU ends up cost you 5% in poorer fuel economy.
http://www.swri.edu/3pubs/IRD1999/08910 ... 003/o2.htm