Here's a link to one of the first lectures of the Internal Combustion Engines class I'm in:
http://www.me.gatech.edu/energ...s.pdf
The greatest stress on a conrod is at TDC after the exhaust stroke. Fastest piston speed is usually about 80-85* ATDC(not 90* as most people believe).
BTW - crankshaft offset = stroke/2
Most aftermarket pistons I've seen weighed are on the order of about +/- 50 grams from stock. So you really don't lose much there and might even gain some, although the rods can sometimes be a fair bit lighter(~50-100 grams). More material = more strength, so aftermarket pistons usually put a priority on beefing them up rather than making them light. Although I imagine some N/A applications could be as much as 100-150 grams lighter than stock, but would probably be just as strong/weak.