Change the fuel filter if it hasn't been changed within the past two years - this probably won't help with the acceleration since you have a misfire, but it is a wise idea to change it regardless.
Inspect your radiator cap according to
this TSB and replace with a new OEM one if necessary.
What is the manufacturing date of your Pathfinder?
You may wish to look into checking your power valve screws and proactively applying red threadlocker to them. See
this thread for more information and a pretty decent DIY guide. This issue doesn't sound like it pertains to your QX4 since there is no oil being consumed and there is no smoking, but one can never be sure.
How's the transmission fluid look?
1. Drive around for 10 minutes in the city after the transmission is at operating temperature.
2. Park on a level surface and apply the parking brake.
3. With P selected, shift through every gear and return to P.
4. Pull the transmission dipstick with the engine idling, wipe it clean, reinsert it completely, and read the level. It must be within the notched area labeled "HOT". Check for fluid contamination after wiping on a paper towel.
The fluid should be red, and not smell burnt.
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