Yes it is safe to go 2.5".
Benefits are lower restrictions and cooler charged air into the throttle bodies.
Most off the shelf smaller turbos for the z32 will have about a 2" outlets. Remember it not about psi to make power, VOLUME of air is needed.
My old 2" pipes, had to push 16.9 psi to make 388whp. Now with 2.5", I only needed 15.5psi to make the same whp.
Manifolds yes too. All these intake and exhaust allow the turbos to work easier and less stress. Therefore less heat generated too.
I'd suggest talking to SZ, they are the pros they came help you meet your goals.
Here is a good read if you have not read already
http://twinturbo.net/net/viewmsg.aspx?f ... tSearch=10