Thankfully, the modding community is already stepping up to fix the GUI. I understand the counter argument that the GUI was designed for consoles, but it's still a horrible mess irregardless of your preferred input device. Even the GUI devs understand the mess and are working with the mod community to improve it, but higher ups are locking some data features out, namely source files (understandably so). The menu is scaleform/flash, and even before the new creation kit toolset, I'm seeing some GUI mods being put out. Should be only a matter of time now.
As for my thoughts on the game...I love it! TES games feel like the open world is hand crafted instead of copy pasted (I'm looking at you Fallout 3), and Skyrim is no exception. Multiple times I've paused to watch the scenery because it's breath taking. I like the new NPC interactions, but the animations seem more limited than I expected.
I like the new perk system. It gives a wide variety to game play. People complain about the reduced ability count, but I'll take more customization over useless abilities any day.
MOD, if you're on PC, modify your ini files
http://www.skyrimnexus.com/downloads/file.php?id=145 It'll make the map a bit more bearable. I just wish seeing the roads was a possibility. Planning my overland marches has been painful