They DO help and give you better gas mileage to boot. The stock setup is configured to spin the CV's all the time, even in 2WD. R50's have drive flanges at the end of each CV locking the wheel to the CV fulltime. That means that the front diff, driveshaft and CV's all need to be pushed into motion by the rest of the drivetrain even though they're not being used(in 2WD). Putting on manual locking hubs allows you to disconnect the CV's and front drivetrain with the hubs unlocked, thereby reducing rotating mass and the extra power expended by the engine to push the front drivetrain into motion.
When you lift an R50, the CV's are at more of an angle than they would be stock, so by not spinning them all the time you WILL reduce wear on them. Good stuff.
If you have the All-Mode setup though, I would NOT suggest using manual hubs unless you're VERY careful about when you turn 4WD on. Manual hubs MUST BE LOCKED when using the All-Mode 4WD system. If you were to be driving at 25 MPH and switch to 4WD, the center clutch/coupler that sends power to the front wheels will attempt to engage while the front driveshaft and diff are stationary, resulting in some fairly severe grinding and possible damage.
Check into NPORA for more offroad-oriented info on Pathfinders...
http://npora.ipbhost.com